产品货号：
Z22176
中文名称：
NOX2/CYBB抗体
英文名称：
Anti-NOX2/CYBB Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-NOX2/CYBB Antibody |
| 指标别名 | CYBB;Cytochrome b 245 heavy chain;NOX2;p91 PHOX |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | CYBB |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence in the middle region of human NOX2(442-459aa YWLCRDTHAFEWFADLLQ),identical to the related rat and mouse sequences. |
| 实际分子量 | 65KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | NOX2(NADPH OXIDASE 2),also called CYBB(CYTOCHROME b(-245),BETA SUBUNIT),p91-PHOX or GP91-1,is a human gene encoding a glycoprotein.NOX2 is an essential component of phagocytic NADPH-oxidase,a membrane-bound enzyme complex that generates large quantities of microbicidal superoxide and other oxidants upon activation.It is mapped on Xp11.4.NOX2 is a heterodimer composed of an alpha chain of relative molecular mass 23kD and a beta chain of 76 to 82kD.NOX2 assembled on DC phagosomes in a gp91-phox subunit-dependent manner,and that reactive oxygen species were produced in a more sustained manner in immature DC phagosomes than in macrophage phagosomes.As a major player in innate immune responses in neutrophils,NOX2 is also involved in adaptive immunity through its activity in DCs.In heart cells,physiologic stretch rapidly activates reduced-form NOX2 to produce reactive oxygen species(ROS) in a process dependent on microtubules(X-ROS signaling). |
| Uniprot ID | P04839 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | cytochrome b-245,beta polypeptide |
| 蛋白名全称 | Cytochrome b-245 heavy chain |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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